UvA - DARE ( Digital Academic Repository ) GABA - A receptor beta 1 - 3 subunit gene expression in the hippocampus of kindled rats
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چکیده
The effect of Schaffer collateral/commissural fiber kindling on the expression levels of GABA A receptor ill, fiE, and f13 subunit mRNA in the pyramidal and granular neurons of the rat dorsal hippocampus was studied, using semi-quantitative in situ hybridization. In pyramidal neurons of CA1 and CA3, only small changes (10-15%) were found. In dentate granule neurons, the expression level of GABAAR-fl3 mRNA was significantly, enhanced, bilaterally, in animals that were partial or fully kindled. At long-term, 4 weeks after the last convulsion no significant changes were found in pyramidal or granular neurons.
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